We were also reassured by the absence of any signal for increased hospitalization or surgery, which are common concerns with medications that affect gastrointestinal function. If future studies confirm these results, he added, they could reassure clinicians that GLP-1 receptor agonists can be used safely in certain patients with Crohns disease who also have obesity or diabetes
Secondary outcomes examined worsening of depression or anxiety separately, substance use disorders, and self-harm incidents
Probably safe to use if: sealed lyophilized vial at controlled room temperature for less than 1 week, brief reconstituted exposure under 2 hours, no visible changes, and peptide responds normally on initial test dose
Those following a vegan or vegetarian diet should also plan their diets carefully to ensure they meet their protein needs by eating a variety of plant-based protein foods
This pattern is consistent with what researchers would expect for a compound where placebo effects, injury variability, and administration differences all contribute noise to self-reported outcomes
doi: 10.1101/2021.03.11.21253225 199 YelinDMargalitIYahavDRunoldMBruchfeldJ